What is the spectrum of gentamicin?

What is the spectrum of gentamicin?

Gentamicin is bactericidal and is a broad spectrum antibiotic (except against streptococci and anaerobic bacteria). Its mechanism of action involves inhibition of bacterial protein synthesis by binding to 30S ribosomes.

Is gentamicin a narrow spectrum?

Gentamicin is a parenterally administered, broad spectrum aminoglycoside antibiotic typically used for moderate to severe gram negative infections.

What is the therapeutic range for gentamicin?

Gentamicin has a narrow therapeutic range in serum of 5 to 10 mg/l (10.5 to 20.9 µmol/l) for peak levels and 1 to 2 mg/l (2.1 to 4.2 µmol/l) for trough levels.

What covers gentamicin?

Gentamicin is active against a wide range of bacterial infections, mostly Gram-negative bacteria including Pseudomonas, Proteus, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Serratia, and the Gram-positive Staphylococcus.

Why is gentamicin not given orally?

Aminoglycosides such as gentamicin cannot be administered orally for treatment of systemic infection because they are not absorbed from the intact gastrointestinal tract [294]. Analysis of peak and trough concentrations reveal significant interpatient variability within and between studies.

Is erythromycin a narrow-spectrum antibiotic?

Penicillin, tetracycline and erythromycin are broad-spectrum drugs, effective against gram-positive and gram-negative microorganisms.

What type of antibiotic is gentamicin?

Gentamicin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.

Why is gentamicin toxic?

Gentamicin can, however, lead to serious side-effects. Gentamicin is potentially ototoxic (potentially damaging to the organs of the ear, specifically the auditory nerve, cochlea or vestibular system) and nephrotoxic (potentially damaging to the kidney).

What are the examples of narrow-spectrum antibiotics?

Examples of narrow-spectrum antibiotics are the older penicillins (penG), the macrolides and vancomycin. Examples of broad-spectrum antibiotics are the aminoglycosides, the 2nd and 3rd generation cephalosporins, the quinolones and some synthetic penicillins.

Is penicillin a narrow-spectrum antibiotics?

In the 1960s, aminopenicillins, then ureidopenicillins, became the broad-spectrum penicillins in comparison with penicillin G. Until then, the quality of being broad spectrum or narrow spectrum was given to an antibiotic only when referring to a comparator.

Is the narrow spectrum antibiotic?

A narrow-spectrum antibiotic is an antibiotic that is only able to kill or inhibit limited species of bacteria. Examples of narrow-spectrum antibiotics include fidaxomicin and sarecycline.

How is gentamicin sulfate determined by UV Vis spectrophotometry?

Introduction: Gentamicin sulfate is an aminoglycosidic antibiotic, used in severe infections caused by Gram-negative bacteria. UV-Vis spectrophotometry, a simple, high speed and accessible analytical method, is generally suitable for the quantitative determination of pharmaceutical active ingredients in raw materials.

Which is the best method to detect gentamicin?

This makes the HPLC analysis more difficult and challenging. Detection techniques like UV are not sensitive enough to detect low levels of related compounds of gentamicin. Mass spectrometry is the technique of choice for the detection of aminoglycosides including gentamicin because of its high sensitivity and identification of compounds.

Is the HPLC analysis of gentamicin sulfate challenging?

Gentamicins are basic, water-soluble, relatively stable, structurally and closely related compounds without UV absorbing chromophores. This makes the HPLC analysis more difficult and challenging.

What kind of side effects can gentamicin cause?

Gentamicin is a complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage.