What is CD30 positive lymphoma?

What is CD30 positive lymphoma?

Primary cutaneous CD30-positive large cell lymphoma (CD30+ PCLCL) is a rare subtype of cutaneous T-cell lymphoma (CTCL) that can present in a variety of ways. We report a patient with a three-month history of an enlarging, exophytic mass with two smaller satellite lesions on the left forearm.

Is AITL CD30 positive?

Using a CD30 cutoff of 5%, prior studies have demonstrated that 63% of patients with AITL were CD30 positive, but only 5% were strongly positive (defined as greater than 50% of cells), thus potentially contributing to some of this discrepancy.

What is CD30 in cancer?

It is a receptor for a protein called tumor necrosis factor, which is involved in cell growth and cell survival. The CD30 protein may be found in higher than normal amounts on some types of cancer cells, including lymphoma cells.

What is CD30 expression?

CD30 is a member of the tumor necrosis factor receptor superfamily. It is characteristically expressed in certain hematopoietic malignancies, including anaplastic large cell lymphoma and Hodgkin lymphoma, among others.

What is cutaneous lymphoma?

Cutaneous T-cell lymphoma causes scaly patches or bumps called lesions or tumors. The cancer is also known as lymphoma of the skin. It is a type of non-Hodgkin lymphoma. Cutaneous T-cell lymphoma is usually a slow-growing cancer.

What is CD15 and CD30?

Abstract. Coexpression of CD30 and CD15 is typically associated with classic Hodgkin’s lymphoma (HL). Peripheral T-cell lymphomas (PTCLs) can often display histologic features that simulate classic HL. However, reports of PTCLs coexpressing both CD30 and CD15 have been infrequently described.

What is vedotin?

Brentuximab vedotin contains a monoclonal antibody that binds to a protein called CD30, which is found on some lymphoma cells. It also contains an anticancer drug, which may help kill cancer cells. Brentuximab vedotin is a type of antibody-drug conjugate. Also called Adcetris and SGN-35.

What is a CD30 test?

CD30 immune staining: A laboratory test is performed on the fluid that was obtained to detect the presence of CD30, a substance that occurs when T-cell lymphocytes are activated. If CD30 is present, it indicates that BIA-ALCL cannot be ruled out and further tests are required.

Is it Hodgkin or Hodgkin’s lymphoma?

Hodgkin’s lymphoma — formerly known as Hodgkin’s disease — is a cancer of the lymphatic system, which is part of your immune system. It may affect people of any age, but is most common in people between 20 and 40 years old and those over 55.