What is adenosine mechanism of action?

What is adenosine mechanism of action?

Mechanism of Action Adenocard (adenosine injection) slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome.

What is the function of adenosine drug?

Adenosine is used as a prescription-only drug for a heart condition marked by episodes of rapid heart rate (paroxysmal supraventricular tachycardia).

How is adenosine metabolized?

Drug Metabolism Adenosine has a rapid onset of action with a very short half-life and undergoes rapid intracellular metabolism, either by phosphorylation, forming adenosine monophosphate, or deamination.

What drug class is adenosine?

Because of the effects of adenosine on AV node-dependent SVTs, adenosine is considered a class V antiarrhythmic agent. When adenosine is used to cardiovert an abnormal rhythm, it is normal for the heart to enter ventricular asystole for a few seconds.

Why does adenosine stop heart?

Adenosine is one of components of RNA, but given intravenously, it works to terminate SVTs by binding to the AV node’s A1 receptors. This inhibits adenylyl cyclase, ultimately increasing potassium efflux from the cell, causing hyperpolarization, and thereby “blocking” the AV node.

When should you not take adenosine?

Patients with irregular heart rates, especially atrial fibrillation, patients with PSVT mimics such as atrial flutter with 2:1 conduction or sinus tachycardia in a dehydrated or stressed patient should never receive adenosine. Adenosine should never be used in wide irregular tachycardias.

What increases adenosine?

The accumulation of adenosine in the body is related to the quantity of caffeine consumed during the day. By drinking beverages with high levels of caffeine, the body builds up an excessive amount of adenosine.

How does it feel to be given adenosine?

Option number one is a medication that works about 90% of the time, but it causes a horrible feeling when it is given. Some people describe it as chest pain. Others say is feels like they are going to die.

What kind of drug is Adenosine used for?

Adenosine is a medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Adenosine: Uses, Interactions, Mechanism of Action | DrugBank Online Online Browse Drugs Categories Pathways Drug Reactions Drug Classification Drug Targets Pharmaco-genomics Pharmaco-metabolomics Pharmaco-transcriptomics

How is Adenosine used in the treatment of sinus rhythm?

Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy in patients unable to adequately exercise.12It is also indicated to convert sinus rhythm of paroxysmal supraventricular tachycardia.13 Accelerate your drug discovery researchwith the industry’s only fully connected ADMET dataset, ideal for:

What kind of acid is 5’adenosine monophosphate?

Adenosine monophosphate, also known as 5′-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine.

How does adenosine work in the renal afferent arterioles?

Adenosine is a potent vasodilator in most vascular beds, but vasoconstriction is produced in renal afferent arterioles and hepatic veins. The drug produces a net mild to moderate reduction in systolic, diastolic, and mean arterial blood pressure and a reflex increase in heart rate.