What are vesicant drugs used for?
Vesicants: Drugs that can result in tissue necrosis or formation of blisters when accidentally infused into tissue surrounding a vein. They include Actinomycin D, Dactinomycin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitomycin C, Vinblastine, Vindesine, Vincristine, and Vinorelbine.
How is vesicant treated?
Treatment of a vesicant extravasation includes immediate cessation of infusion, aspiration of as much extravasated drug as possible through the still-intact catheter, and attempts for the aspiration of the extravasated agent in the surrounding tissue. This aspiration may help to limit the extent of tissue damage.
Which chemo drug is an irritant with vesicant properties?
Chemotherapy vesicant & irritant properties and suggested management for extravasation
|Drug||Vesicant or Irritant|
|Daunorubicin liposomal (DaunoXome)||Irritant|
|Docetaxel (Taxotere)||Irritant (usually) Vesicant (rare)|
|Pegylated liposomal doxorubicin (Doxil)||Irritant|
What are examples of vesicant solutions?
Some common examples of vesicant medications and fluids include vancomycin, potassium chloride, calcium gluconate, dopamine, and Dilantin.
How do you administer vesicant drugs?
Inject or infuse the vesicant medication through the Y-site needleless connector of a free-flowing IV solution such as 0.9% sodium chloride solution. This additional fluid helps dilute the drug and reduces the risk of vein damage.
How do you manage infiltration?
How is it treated?
- Elevate the site as much as possible to help reduce swelling.
- Apply a warm or cold compress (depending on the fluid) for 30 minutes every 2-3 hours to help reduce swelling and discomfort.
- Medication-If recommended, medicine for extravasations is given within 24 hours for best effect.
Why should vesicants be given first?
If more drugs must be administered, vesicants should be administered first because veins will not have been irritated by other agents and because post-vesicant flushing will preserve venous integrity (BIII).
Why are vesicants given first?
What is a non vesicant drug?
Non-vesicants are IV solutions and medication that do not cause ischemia or necrosis.
Can I sue for IV infiltration?
Filing a Medical Malpractice Claim or Lawsuit After a Complication Related to an IV. Most victims who have suffered a severe case of IV infiltration can seek monetary compensation through medical malpractice claims or lawsuits to hold those negligent accountable for their actions.
Which is the best antibiotic for the vesicant?
not present Vesicant agent Antidote Local treatment Alkylating agent (nitrogen mustard) Sodium thiosulfate Cooling pack Extremity elevation Anthracyclines (daunorubicin, doxorubici Dexrazoxane Cooling pack Extremity elevation Antitumor antibiotics (dactinomycin, mit None known Cooling pack
Which is an irritant and which is a vesicant?
Some antineoplastic agents may be classified as a vesicant, others as an irritant, and some as an irritant with vesicant properties, depending on the effect on surrounding tissue when the agent leaks outside the vein.15,17 A vesicant (Box 1) is any drug that has the potential to cause tissue damage when leakage occurs outside the vein.13
Can a mannitol monitor detect a vesicant?
Mannitol (≥5%) Vesicant Monitor No (E, F) Yes Central line preferred; in emergency, Dextrose (≥10%) Vesicant Monitor No (B) Yes push slowly, monitor for extravasation Magnesium sulfate Irritant Yes Yes Yes Peripheral concentrations only: refer to electrolyte replacement protocols
Is there a contrast-radiographic vesicant monitor at IMED?
Contrast – Radiographic Vesicant Monitor Yes Yes Only high pressure injector midlines (all Intermountain approved midlines) Prepared at IMED by Laura MacCall, PharmD and Whitney Buckel, PharmD Last Updated Sept 18, 2016