Is platelet clumping normal?

Is platelet clumping normal?

A normal platelet count, even with clumping seen on a smear, is still usually estimated to be normal (or may occasionally be increased.) Thrombocytopenia, on the other hand, can be a challenge in the hematology laboratory. With thrombocytopenia, physicians need an accurate count to diagnose, treat or monitor patients.

What medications can cause platelet clumping?


  • Furosemide.
  • Gold, used to treat arthritis.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Penicillin.
  • Quinidine.
  • Quinine.
  • Ranitidine.
  • Sulfonamides.

What causes platelet clumping EDTA?

2, 3 Platelet clumping in the presence of EDTA is caused by an autoantibody against glycoprotein IIb/IIIa located on the cell membrane of platelets. 4, 5 Although other anticoagulants such as heparin and sodium citrate rarely induce such a phenomena, it is possible.

How do you test for platelet clumping?

A platelet aggregation test requires a blood sample. The sample is initially examined to see how the platelets are distributed through the plasma, the liquid part of the blood. A chemical is then added to your blood sample to test how quickly your platelets clot.

What causes sudden decrease in platelet counts?

A temporary drop in the platelet count is common among heavy drinkers, especially if they’re eating foods that are low in iron, vitamin B12, or folate. Chickenpox, mumps, rubella, Epstein-Barr virus, or parvovirus can decrease your platelet count for a while.

What causes the clumping of platelets during an anaphylactic reaction to occur?

Other substances released as a result of the anaphylactic reaction are platelet-activating factor (PAF) and bradykinin. PAF is released from mononuclear phagocytes, platelets and some endothelial cells in response to anaphylaxis . PAF causes the aggregation or clumping of platelets.

What causes abnormal platelet count?

According to the Mayo Clinic, in primary thrombocythemia, a high blood platelet count is caused by a bone marrow disorder where faulty cells in the bone marrow are producing too many platelets (and the platelets being produced are abnormal). In secondary thrombocytosis, however, the underlying condition is the cause of the high blood platelet count.

What causes large platelets?

Large platelets in ovulation may be caused due to an autoimmune disorder in which the platelets begin to be destroyed due to the body’s own immune system. Large platelets in the first trimester may be due to an infection or any underlying condition in which the bone marrow fails to produce enough platelets.