Does MGUS cause bone cancer?

Does MGUS cause bone cancer?

The most common condition linked with these abnormal proteins is monoclonal gammopathy of undetermined significance (MGUS). It is not cancer. But people with MGUS have a greater risk of getting serious diseases of the bone marrow and blood.

Is MGUS a bone marrow disorder?

This protein is called monoclonal protein, or M protein. It’s made by white blood cells called plasma cells in the body’s bone marrow. Usually, MGUS isn’t a cause for concern and has no adverse health effects. However, people with MGUS have a slightly increased risk of developing blood and bone marrow diseases.

How do you know if MGUS is progressing?

People with MGUS need to be monitored with blood and urine testing every 6 to 12 months to determine if MGUS is progressing. For a small percentage of individuals, the condition develops into cancerous conditions, such as multiple myeloma or lymphoma.

Can MGUS cause bone pain?

Signs and Symptoms This may be due to nerve damage caused by the paraprotein in the blood. Patients with MGUS should watch for any symptoms, such as bone pain and fatigue, as they might indicate progression to myeloma.

Does MGUS affect immune system?

The immune status of patients with MGUS or MM has to be seen in the light of the aging immune system. Qualitative as well as quantitative changes in the humoral immune response occur with late age. The B-cell repertoire and maturation response are critical in mediating protection against infection (41).

Can I donate blood if I have MGUS?

Permanent deferral of blood donors with stable MGUS causes about a 1% loss of potential blood donations and it represents a “precautionary measure” that needs to be substantiated and validated.

Is exercise good for MGUS?

Whole-body vibration exercise improves physical performance in MGUS patients. Muscle strength and endurance are improved after WBV in MGUS. Whole-body vibration increases cortical bone mineral density in female participants.

Does MGUS cause bone loss?

Monoclonal gammopathy of undetermined significance (MGUS) is the most common plasma cell disorder, and it may progress to multiple myeloma or a related B-cell disorder. Notably, patients with MGUS have increased rates of bone resorption, osteopenia, osteoporosis, and risk of fractures.

Can MGUS cause bone lesions?

The prevalence of MGUS increases with age, and is higher in men than in women. Patients with MM have a high incidence of bone disease, including osteopenia, osteolytic lesions, and fractures, which can significantly increase morbidity and mortality in patients with MM.