Why does ATP production via oxidative phosphorylation require an intact mitochondrial membrane?
Why does ATP production via oxidative phosphorylation require an intact mitochondrial membrane? The mitochondrial inner membrane allows a hydrogen ion gradient to form, and this gradient powers ATP production. These cell types thus produce about two extra moles of ATP per glucose than other cell types do.
Why does oxidative phosphorylation occur in the inner mitochondrial membrane?
The outer membrane is very permeable, and it allows many molecules to flow in and out of the mitochondrion. The inner membrane, which is much less permeable, is the site of oxidative phosphorylation.
How is ATP produced in oxidative phosphorylation in mitochondria?
Oxidative phosphorylation is the process in which ATP is formed as a result of the transfer of electrons from NADH or FADH 2 to O 2 by a series of electron carriers. This process, which takes place in mitochondria, is the major source of ATP in aerobic organisms (Figure 18.1).
What is the role of the mitochondrial membrane in ATP synthesis?
What Is the Purpose of a Mitochondrial Membranes? The inner membrane is also loaded with proteins involved in electron transport and ATP synthesis. This membrane surrounds the mitochondrial matrix, where the citric acid cycle produces the electrons that travel from one protein complex to the next in the inner membrane.
What is the net yield of ATP in oxidative phosphorylation?
Oxidative phosphorylation produces 24–28 ATP molecules from the Kreb’s cycle from one molecule of glucose converted into pyruvate.
What complex of ATP synthase is responsible for the synthesis of ATP?
The human mitochondrial (mt) ATP synthase, or complex V (EC 3.6. 3.14) is the 5th multi subunit oxidative phosphorylation (OXPHOS) complex. It synthesizes ATP from ADP in the mitochondrial matrix using the energy provided by the proton electrochemical gradient (Capaldi et al.
Which is the site of oxidative phosphorylation in mitochondria?
The electron transport chain
The electron transport chain in the cell is the site of oxidative phosphorylation.
What is the mechanism of ATP synthase?
The ATP synthase is a mitochondrial enzyme localized in the inner membrane, where it catalyzes the synthesis of ATP from ADP and phosphate, driven by a flux of protons across a gradient generated by electron transfer from the proton chemically positive to the negative side.
What are the two stages of oxidative phosphorylation?
This oxidative-phosphorylation process consists of two steps: the oxidation of NADH (or FADH2) and the phosphorylation reaction which regenerates ATP.