Which of the following drug is a 5-lipoxygenase inhibitor?

Which of the following drug is a 5-lipoxygenase inhibitor?

Zileuton, a benzothiophene N-hydroxyurea, is the only approved inhibitor of 5-lipoxygenase (5-LOX, EC number 1.13.

Which drug used for the treatment of asthma inhibits 5-lipoxygenase?

Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma.

What do lipoxygenase inhibitors do?

Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.

Does montelukast inhibit 5-lipoxygenase?

Moreover, montelukast directly inhibited human recombinant 5-lipoxygenase. Kinetic experiments revealed that the inhibition was of the non-competitive type, suggesting that montelukast binds a yet undefined allosteric site on 5-lipoxygenase.

Which drug is a leukotriene inhibitor?

Leukotriene-Inhibiting Drugs The leukotriene receptor antagonists include zafirlukast (Accolate) and montelukast (Singulair); zileuton (Zyflo) is the only leukotriene synthesis inhibitor (Table 1).

What does the lipoxygenase pathway produce?

5-lipoxygenase (5-LO) pathway is the major source of potent proinflammatory leukotrienes (LTs) issued from the metabolism of arachidonic acid (AA), and best known for their roles in the pathogenesis of asthma.

Which of the following medications inhibits the action of 5-lipoxygenase and consequently the action of leukotriene?

Zileuton (Zyflo, Zyflo CR) It is a 5-lipoxygenase inhibitor.

What is the 5 LOX pathway?

How do you stop leukotrienes?

Drugs such as montelukast (Singulair) and zafirlukast (Accolate) are widely prescribed to treat exercise and allergy-induced asthma. A third drug called zileuton (Zyflo) indirectly inhibits leukotriene synthesis. Montelukast is also prescribed for the treatment of year-round and seasonal allergic rhinitis.

What causes overproduction of leukotrienes?

Leukotrienes are signaling molecules that are responsible for many allergic and inflammatory reactions. Their overproduction is attributed to the nasal polyps, asthma, and aspirin sensitivity experienced by individuals with Samter’s Triad/AERD.

What is a leukotriene modifier inhaler?

Leukotriene modifiers, also called leukotriene receptor antagonists, are a group of medications. They can help prevent breathing problems associated with allergies, asthma and chronic obstructive pulmonary disease. Examples include montelukast, zafirlukast and zileuton.