What is TRP2?

What is TRP2?

TRP2. Tyrosinase-related protein-2 (TRP2) is another melanocyte differentiation antigen. 12. It is an enzyme, dopachrome tautomerase (DCT), which is involved in the modification of the pigment color. The absence of TRP2 does not lead to a loss of pigmentation, but rather to a color modification.

Is tyrosinase a protein?

Tyrosinase-related protein, also known as catalase B and gp75, is a melanocyte-specific protein whose precise function is not well understood. Various roles may include stabilizing tyrosinase, regulating melanin production through peroxide levels, and determining the shape of melanosomes.

How is tyrosinase TYRP1 related to melanin?

The TYRP1 gene provides instructions for making an enzyme called tyrosinase-related protein 1. This enzyme is located in melanocytes, which are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color.

Is melanin a protein?

Melanin is a highly irregular heteropolymer consisting of monomeric units derived from the enzymatic oxidation of the amino acid tyrosine. The process of melanin formation takes place in specialized acidic organelles (melanosomes) in melanocytes. It is known that melanin is always bound to protein in vivo.

Which chromosome is TYRP1 on?

chromosome 9p23
Oculocutaneous albinism type 3 (OCA3; OMIM 203290) results from mutations in TYRP1, located at chromosome 9p23 (369–371), and which encodes a 537 amino acid TYRP1 polypeptide with molecular weight of approximately 60 kDa (372,373).

What causes lack of melanin in the body?

Pregnancy, Addison’s disease, and sun exposure all can make your skin darker. If your body makes too little melanin, your skin gets lighter. Vitiligo is a condition that causes patches of light skin. Albinism is a genetic condition affecting a person’s skin.

How do you produce more melanin?

Eating vitamin C–rich foods like citrus, berries, and leafy green vegetables may optimize melanin production. Taking a vitamin C supplement may help as well. Shop for vitamin C.