What is the receptor for CCL2?

What is the receptor for CCL2?

CCL2 (monocyte chemoattractant protein-1, MCP-1) is a potent chemokine for monocytes, and a variety of other immune cells. Its receptor is CCR2, which is expressed at high levels on monocytes. CCL2 is produced by osteoblasts in response to PTH and proinflammatory cytokines.

What is the role of MCP-1?

Monocyte chemoattractant protein-1 (MCP-1) is the most important chemokine that regulates migration and infiltration of monocytes/macrophages. MCP-1 is highly expressed in atherosclerotic plaques in response to cytokines, growth factors, oxLDL, and CD40L.

What produces CCL2?

CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. Platelet derived growth factor is a major inducer of CCL2 gene.

What is CCR2 gene?

CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Human Immunodeficiency Virus Type 1 and Idiopathic Anterior Uveitis. Among its related pathways are A-beta Uptake and Degradation and Akt Signaling.

Is MCP-1 a proinflammatory cytokine?

MCP-1 plays a clear proinflammatory role in skeletal muscle, since specific muscular overexpression of MCP-1 in mice increases the expression of IL-1β and the macrophage markers F4/80 and CD68 in the gastrocnemius muscle [42].

Is CCL2 deficient?

Ccl2 deficiency reduced the number of infiltrating mononuclear cells and expression of Ccl5, Ccl7, Ccl8, Ccr2 and Cd206. We conclude that Ccl2 is a critical mediator of chronic renal injury in RVH.

Is MCP-1 inflammatory?

In summary, our data suggest that MCP-1 may be a necessary component of the inflammatory response required for adipose tissue protection, remodeling, and healthy expansion in the FVB/N strain in response to HFD feedings.

Do macrophages express CCR2?

Since CCR2 is expressed primarily on classically derived, pro-inflammatory macrophages, we hypothesized that inadequate early influx of these cells accounts for the impaired wound healing phenotype in CCR2-deficient mice.

Where is CCR5 found?

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3.

Is CCl2 a Electrophile?

Dichlorocarbene (CCl2) is generally regarded as an electrophilic carbene that preferentialy adds to electron-rich (nucleophilic) alkenes. However, a singlet carbene like CCl2 is inherently both an electrophile and a nucleophile.