What is the difference between MCC 101 and 102?

What is the difference between MCC 101 and 102?

Avicel PH 101 is the original grade of MCC, while PH 102 is available as a partially agglomerated product with a larger particle size distribution and slightly better fluidity. Both grades show no significant difference in the compressibility [78].

What MCC 102?

Microcrystalline Cellulose MCC 102 Microcrystalline Cellulose (MCC) is an odourless, tasteless, porous powder derived from pharmaceutical grade wood pulp. What industries is Microcrystalline Cellulose used in? Food production, pastry, cosmetic, nutraceutical and pharmaceutical industries.

What is avicel used for in tablets?

Avicel is used to extend starches, stabilize foams, and control ice crystal formation. Avicel has found widespread acceptance in the food industry for meringue, whipped toppings, confections, and ice cream, and is also used as a binder in pharmaceutical tablets and in cosmetics.

What is Avicel PH?

Avicel® PH is an ideal wet granulation binder which rapidly produces robust granules that remain stable in high shear environments, enabling broad processing windows and maximizing batch to batch reproducibility.

Why is microcrystalline cellulose used in vitamins?

That’s right, it’s sawdust. Like silica, microcrystalline cellulose is also a relatively harmless filler that is used as an anti-caking agent, an emulsifier, and a capsule-filler in supplements. It is sometimes used as an anti-caking agent in powdered or capsulated supplements.

What is MCC excipient?

Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC).

Does lactose cause sticking?

Lactose exhibits erosion type disintegration pattern whereas Microcrystalline Cellulose exhibits bursting type disintegration pattern. Both are combined to overcome the long DT of Lactose as well as to prevent the sticking and heap formation tendency in dissolution testing.

What is Avicel CL 611?

Avicel RC / CL is a colloidal, water dispersible, spray-dried blend of microcrystalline cellulose and carboxymethylcellulose sodium. Formulations which include this excipient have high thixotropy, low viscosity and display reduced settling or sedimen.

What is avicel ph101?

Description. Avicel PH, FMCs innovator brand of microcrystalline cellulose, is a purified, partially depolymerized alpha-cellulose made by acid hydrolysis of specialty wood pulp. The process of polymerization involves high levels of quality and stringency.

Is microcrystalline cellulose in supplements safe?

According to the Select Committee on GRAS Substances, microcrystalline cellulose is generally regarded as safe when used in normal quantities.

What is MCC used for?

Microcrystalline cellulose (MCC) is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. The most common form is used in vitamin supplements or tablets.

Which is better grade 102 or 301 cellulose?

The manufacturers describe grade 102 as having a larger average particle size (near to 100 μm for most grades and 130 for JRS’s products) and it is suggested for direct compression. Grades 301 and 302 are described as the same quality as grades 101 and 102, and are therefore recommended for the same procedures, but with a higher bulk density.

How are MCC compared to the other grades?

Then, each MCC is compared against the others of the same grade. Although they are usually described by the manu- facturers similarly, the results indicate that there may be large differences between them.

Which is better grade 101 or 102 Avicel?

Both are deficient values due to the low MCC density. However, grade 101 has a higher “Compressibility” value (7.80) than grade 102 (6.63), as described above in the comparison of Avicel®, owing to a decrease in IC and Ie. Despite the “Compressibility” decrease, grade 102 only shows slightly higher “Flowability”.

How is microcrystalline cellulose ( MCC ) prepared?

More than 50 years later, MCC is manufactured globally by more than 10 suppliers. MCC is a purified, partially depolymerized cellulose prepared by treating alpha cellulose (type I β ), obtained as a pulp from fibrous plant material, with mineral acids.