What drug class is Methazolamide?

What drug class is Methazolamide?

Methazolamide is in a class of medications called carbonic anhydrase inhibitors. It works by decreasing the pressure in the eye.

How do you do BCS solubility?

For the thermodynamic solubility of a compound, determine λmax of UV-Vis spectrophotometry (180 to 750 nm) out of the cut-off range of the solvent. Based on Beer-Lambert absorbance law (A=εbc and A<1), adjust the concentration (mostly between 10-5 to 10-4 M) and draw the calibration curve (y = ax + b).

How is BCS classification determined?

The drugs are classified in BCS on the basis of solubility, permeability, and dissolution. Solubility class boundaries are based on the highest dose strength of an immediate release product.

What is the mechanism of action of Methazolamide?

Mechanism of Action. Methazolamide is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.

What are the problems with BCS Class IV drugs?

BCS class IV drugs (e.g., amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel) exhibit many characteristics that are problematic for effective oral and per oral delivery. Some of the problems associated include low aqueous solubility, poor permeability, erratic and poor absorption, inte …

How is methazolamide used in the treatment of glaucoma?

Methazolamide is topical carbonic anhydrase inhibitor. Methazolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers.

When to use BCS-based biowaivers in drug development?

BCS-based biowaivers are applicable to drug products where the drug substance(s) exhibit high solubility and, either high permeability (BCS Class I) or low permeability (BCS Class III).