What does IFN gamma do to T cells?
Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it may enhance anti-tumor and antiviral effects of CD8 T cells.
Do T cells produce IFN gamma?
The pleiotropic cytokine IFN-γ is produced primarily by activated T cells and NK cells. The cellular effects of IFN-γ are mediated by its heterodimeric cell surface receptor IFN-γR. The IFN-γR is comprised of α- and β-chains, both of which belong to the class II family of cytokine receptors (1, 2).
What is IFN gamma used for?
Interferon gamma-1b injection is used to reduce the frequency and severity of serious infections in people with chronic granulomatous disease (an inherited immune system disease). It is also used to slow down worsening of their condition in people with severe, malignant osteopetrosis (an inherited bone disease).
What type of IFN is IFN gamma?
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
What stimulates IFN-gamma?
IFN‐γ is primarily secreted by activated T cells and natural killer (NK) cells, and can promote macrophage activation, mediate antiviral and antibacterial immunity, enhance antigen presentation, orchestrate activation of the innate immune system, coordinate lymphocyte–endothelium interaction, regulate Th1/Th2 balance.
What does interferon gamma do to the body?
How does IFN-gamma work?
Specifically, IFN-γ plays a major role in activating anticancer immunity, by promoting the activity of CD4 T helper type 1 cells, CD8 cytotoxic T lymphocyte (CTL), natural killer (NK) cells, dendritic cells (DCs), and macrophages, promoting the antigen presentation.
What stimulates IFN gamma?
How is T-bet regulated by DCs and IFN-γ?
The rapid up-regulation of T-bet by IFN-γ in DCs coupled with a function for DC-derived IFN-γ in T cell activation may constitute a positive feedback loop to maximize type 1 immunity. Dendritic cells (DCs) are professional antigen-presenting cells with a remarkable capacity to activate naive T cells ( 1, 2 ).
Why is T-bet required for optimal production of IFN-γ?
However, T-bet was essential for the optimal production of IFN-γ by both CD8α + and CD8α – DCs. T-bet-deficient DCs were significantly impaired in their capacity to secrete IFN-γ after both stimulation with IL-12 alone or in combination with IL-18.
How does retroviral gene transduction of T bet work?
Retroviral gene transduction of T-bet into primary T cells or developing Th2 cells results in activation of IFN-γ production ( 21 ), whereas mice lacking T-bet fail to develop Th1 cells and display a dramatic reduction of IFN-γ production by CD4 + T cells ( 22 ).
Where are the laboratories for human T bet?
20 St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, 75015 Paris, France; University of Paris, Imagine Institute, 75015 Paris, France.