Can a person with Wolf-Hirschhorn syndrome have kids?

Can a person with Wolf-Hirschhorn syndrome have kids?

A loss of these genes results in the intellectual disability , slow growth, and other health problems characteristic of Wolf-Hirschhorn syndrome. If a parent is found to have a balanced translocation involving chromosome 4, they may be at risk of having additional children with Wolf-Hirschhorn syndrome.

Is Wolf-Hirschhorn syndrome curable?

There is no cure for Wolf-Hirschhorn syndrome, and every patient is unique, so treatment plans are tailored to manage the symptoms. Most plans will include: Physical or occupational therapy. Surgery to repair defects.

How common is Wolf-Hirschhorn syndrome?

The prevalence of Wolf-Hirschhorn syndrome is estimated to be 1 in 50,000 births. However, this may be an underestimate because it is likely that some affected individuals are never diagnosed. For unknown reasons, Wolf-Hirschhorn syndrome occurs in about twice as many females as males.

Why is it called Wolf-Hirschhorn syndrome?

The syndrome is named for the American Kurt Hirschhorn and German U. Wolf who independently found the 4p- chromosome abnormality in the 1960s.

Is Wolf-Hirschhorn syndrome detectable before birth?

Prenatal diagnosis of WHS is usually confirmed by detection of a cytogenetically visible 4p- deletion discovered after invasive testing performed because of advanced maternal age, severe IUGR (which is the most frequent ultrasound finding, associated or not with other fetal abnormalities), or known parental balanced …

What is it like living with Wolf-Hirschhorn Syndrome?

Answer. The long-term outlook ( prognosis ) for people with Wolf-Hirschhorn syndrome (WHS) depends on the specific features present and the severity of those features. The average life expectancy is unknown. Muscle weakness may increase the risk of having chest infections and ultimately may reduce the life expectancy.

Why is it called Wolf-Hirschhorn Syndrome?

Is Wolf-Hirschhorn Syndrome detectable before birth?

Are there prenatal tests for Wolf-Hirschhorn Syndrome?

Noninvasive prenatal testing (NIPT) is one very promising screening tool for WHS. SNP array can improve diagnostic precision for detecting WHS, especially for the cryptic aberrations that cannot be identified by the traditional karyotyping.

What is the long term outlook for a child with Wolf-Hirschhorn syndrome?

The long-term outlook ( prognosis ) for people with Wolf-Hirschhorn syndrome (WHS) depends on the specific features present and the severity of those features. The average life expectancy is unknown. Muscle weakness may increase the risk of having chest infections and ultimately may reduce the life expectancy.

Why is it called Wolf Hirschhorn Syndrome?

Does Wolf Hirschhorn syndrome have a cure?

There is no cure for Wolf-Hirschhorn syndrome, and every patient is unique, so treatment plans are tailored to manage the symptoms. Most plans will include: National Organization for Rare Disorders: “Wolf Hirschhorn Syndrome.” National Center for Biotechnology Information, Gene Reviews: “Wolf-Hirschhorn Syndrome.”

What causes Wolf Hirschhorn syndrome?

Wolf-Hirschhorn syndrome is caused by a deletion of genetic material near the end of the short (p) arm of chromosome 4.

Are there prenatal tests for Wolf Hirschhorn syndrome?

People who known themselves to be carriers of Wolf–Hirschhorn syndrome must undergo genetic testing and counseling prior to starting a family as this would prevent the disorder from getting transmitted to the child. Prenatal screening is advisable to families that have one parent as a carrier of the syndrome.

Is Wolf Hirschhorn syndrome contagious?

Wolf and Hirschhorn described that the traits of the syndrome were associated with a deletion of part of the short arm of chromosome 4. Wolf Hirshhorn Syndrome is a contagious gene syndrome.